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The purpose of the present study was to characterize the acute inhibitory effects of restraint stress on the activity of tuberoinfundibular dopamine DA neurons as estimated by measuring concentrations of 3,4-dihydroxyphenylacetic acid DOPAC in the median eminence. The time course of the effects of two types of physical restraint immobilization in the supine position or confinement in an acrylic cylindrical tube was determined in unanesthetized and diethylether ether -exposed female and male rats. The combination of brief 2 min exposure to ether followed by 10 and 20 min of supine restraint increased concentrations of prolactin in plasma and decreased DOPAC concentrations in median eminence of both female and male rats.
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