Luke's International Hospital, Tokyo, Japan. We review the current status of multidisciplinary care for patients with inflammatory breast cancer IBC and discuss what further research is needed to advance the care of patients with this disease. We performed a comprehensive review of the English-language literature on IBC through computerized literature searches.
The purpose of this study was to evaluate whether the survival of women with inflammatory breast cancer IBC treated at our institution has improved over the past 30 years. Three-hundred ninety-eight patients with IBC were treated between and Patient characteristics and outcomes were tabulated and compared among decades of diagnosis.
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Inflammatory breast cancer IBC is the most aggressive manifestation of primary breast carcinoma, with the clinical and biological characteristics of a rapidly proliferating disease. The multidisciplinary management of IBC has changed in the past 3 decades and is presently clearly outlined in sequence, with preoperative or neoadjuvant chemotherapy representing the mainstay of treatment. Anthracyclines and taxanes are the most effective cytotoxic agents in the management of primary breast cancer and should be the standard of treatment for women with IBC. Locoregional treatment includes radiotherapy with or without surgery and continues to play a major role after appropriate medical treatment.
This summary discusses primary epithelial breast cancers in women. The breast is rarely affected by other tumors such as lymphomas, sarcomas, or melanomas. Refer to the following PDQ summaries for more information on these cancer types:.
IBC is a designated health disparity due to its increased incidence and mortality amongst minority populations both in the US and globally. With improved awareness, its detection has increased, especially in large clinical centers [ 3 ]. It is therefore clear that IBC tumor cells develop mechanisms to evade therapeutic apoptosis leading to cancer recurrence.
Inflammatory breast cancer  IBC is one of the most aggressive types of breast cancer that can occur in women of any age and, extremely rarely, in men. It is called inflammatory because it frequently presents with symptoms resembling an inflammation. Despite the name, whether inflammation contributes to the development of "inflammatory breast cancer" remains an area of ongoing research.
Inflammation has been recognized as an important driver in the development and growth of malignancies. Inflammatory signaling in cancer emerges from the combinatorial interaction of several deregulated pathways. Pathway deregulation is often driven by changes in the underlying gene regulatory networks.
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